Determination of six active components in Zhikechuanbeipipa dropping pills by UPLC-Q-TOF / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 830-833, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-860734
ABSTRACT
OBJECTIVE:
To develop a UPLC-Q-TOF-MS method for determination of six components (guanosine, peiminine, platycodin D, platycodin D3, oleanolic acid and ursolic acid) in Zhikechuanbeipipa dropping pills.METHODS:
The analysis was performed on a Waters Acquity BEH C18 column (2.1 mm×100 mm, 1.7 μm) with the mixture of acetonitrile-water-formic acid as mobile phase, and the flow rate was 0.4 mL·min-1; The PDA detection wavelength was 190-400 nm; The column temperature was room temperature (30°C).RESULTS:
The linear relationship between the concentration and peak areas of the six compounds were all linear (r>0.9996). The average recoveries (n=6) were between 99%-101%.CONCLUSION:
This method was simple, accurate and reliable to determine the six contents of Zhikechuanbeipipa dropping pills for the quality control. Copyright 2012 by the Chinese Pharmaceutical Association.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2012
Type:
Article
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