Analysis of plasticizer in compound aluminum hydroxide tablets with GC-MS/MS / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 384-386, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-860810
ABSTRACT
OBJECTIVE:
To develop GC/MS method in detect plasticizers in compound aluminum hydroxide tablets adsorbed from pharmaceutical packaging.METHODS:
The column HP-5MS silica capillary column (30 m × 0.25 μm, 0.25 mm) was used; Ion source temperature was 230°C; Quadrupole temperature was 150°C; The total ion scanning rang m/z 50~500.RESULTS:
The diethylhexyl phthafate linearity was in the range of 0.5 -20.0 μg · mL-1 with a regression coefficient of 0.9990. The average recovery of this method was 98.8%, and RSD was 1.4%. The RSD of intra-day and inter-day was 2.8% and 3.1% respectively.CONCLUSION:
This method is specificity, sensitive, and can be applied to detect and research DEHP which may be adsorbed or penetrated into drugs. Copyright 2012 by the Chinese Pharmaceutical Association.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2012
Type:
Article
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