Brain targeting of baicalin-phospholipid solution after unilateral nasal administration / 中国药学杂志

ABSTRACT

OBJECTIVE: To investigate the distribution of baicalin-phospholipid solution after unilateral nasal administration in rat blood and left olfactory, right olfactory bulb, left brain, right brain, and the cerebellum, and to evaluate its brain targeting effect. METHODS: After intravenous and unilateral nasal administration of baicalin-phospholipid solution, the concentrations of baicalin-phospholipid in the plasma and the brain tissues of the rats were determined by HPLC. RESULTS: After administration by left nasal cavity, the drug concentration was maximum in the left olfactory bulb, followed by the right olfactory bulb, left brain, right brain, and finally the cerebellum. The olfactory propotion was 100%, 100%, 75.06%, 62.39% and 65.11%, respectively. CONCLUSION: Baicalin can distribute into brain by "nose-brain" transport pathway after intranasal administration of baicalin-phospholipid. Copyright 2012 by the Chinese Pharmaceutical Association.