Quantitative determination of tiopronin injection by Raman spectroscopy / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 232-235, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-860837
ABSTRACT
OBJECTIVE:
To establish a Raman spectroscopy method for the determination of tiopronin injection.METHODS:
Based on Raman scattering theory, the light intensity of the laser Raman peak is in proportional to the concentration of tiopronin samples in aqueous solution. A quantitative method for determination of tiopronin injection using Raman spectroscopy was established by selecting the Raman peak of tiopronin sulfhydryl group (S-H[2580 cm-1]) as quantitative peak.RESULTS:
The calibration curve was linear over the range of 10 - 100 mg · mL-1 (r = 0.9999, n =6), and the average recovery was 101.98% with RSD of 2.09% (n = 9).CONCLUSION:
The method is convenient and rapid. It is expected to be used in the quality control of tiopronin injection. Copyright 2012 by the Chinese Pharmaceutical Association.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2012
Type:
Article
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