Identification of metabolites of senecionine, a hepatotoxic pyrrolizidine alkaloid, by liquid chromatography/tandem mass spectrometry / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 54-60, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-860863
ABSTRACT
OBJECTIVE:
To investigate the metabolic profile of senecionine in rats.METHODS:
Liquid chromatography-tandem mass spectrometry (LC-MSn) mass spectrometry was used for the analysis of senecionine and its metabolites in rats bile, urine, and feces after a single oral dose of senecionine.RESULTS:
In total 38 metabolites were identified, including oxidation products, hydroxylation products, hydrolysis products, sulfation products, glucuronidation products, and GSH-conjugations. And metabolites were found to be more abundant in bile and urine than those in feces.CONCLUSION:
Senecionine undergoes extensive metabolism in rats.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Diagnostic study
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2012
Type:
Article
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