Molecular imaging to detect the immune microenvironment of colorectal cancer / 中国医学影像技术

ABSTRACT

Colorectal cancer is common malignant tumor. Immunotherapy is effective for patients with microsatellite instability and difficulty to treat with conventional chemotherapy. Understanding of tumor immune microenvironment (TIME) will help to improve the response to immunotherapy. Molecular imaging can visualize, characterize and quantify cellular and subcellular processes at the anatomical and molecular levels. Imaging of cell components at TIME can help to understand the dynamic development process of tumor, discover and clarify the molecular mechanism in the pathogenesis of tumor, therefore being assist for the development of effective treatment methods and accurately and effectively prediction of treatment response through identification of biomarkers. The advances in molecular imaging of TIME of colorectal cancer were reviewed in this article.