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Chemical ablation of anterior papillary muscle of canine left ventricle using multifunctional catheter / 中国医学影像技术
Chinese Journal of Medical Imaging Technology ; (12): 976-980, 2020.
Article in Chinese | WPRIM | ID: wpr-860956
ABSTRACT

Objective:

To observe the feasibility of chemical ablation of left ventricular (LV) anterior papillary muscle (APM) using multifunctional intracardiac echocardiography (ICE) catheter.

Methods:

Fifteen hybrid canines were randomly divided into 0.2 ml, 0.4 ml and 0.8 ml injection groups (each n=5). Then the above doses of ethanol were injected into the base of LV APM under the location and monitoring of ICE images in each group, respectively. Mitral regurgitation area (MRA) and vena contracta (VC) were measured with transthoracic echocardiography before and 5 days after ablation. All animals were sacrificed 5 days after ablation, the general and pathological changes of APM were observed.

Results:

ICE images clearly displayed the structure of LV APM and the depth of needle insertion and ablation process in real time. No significant difference of MRA nor VC was detected in 0.2 ml nor 0.4 ml group before and 5 days after ablation, but MRA and VC in in 0.8 ml group were both higher than those before ablation (all P<0.05). Pale ablation lesions in the base of APM were observed, the volume of ablation lesions formed by 0.2 ml, 0.4 ml and 0.8 ml absolute ethanol at the base of APM were (0.37±0.07)cm2, (0.69±0.08)cm2 and (0.96±0.19)cm2, respectively. The volume of ablation lesion in higher dose group was larger than that in lower dose group (all P<0.05). Irreversible necrosis of cardiomyocytes were observed in the ablation site under light microscopy.

Conclusion:

Chemical ablation of APM is effectively and safely achieved with intramyocardial injection of small amount of ethanol, which may provide a new ablation strategy for treatment of ventricular arrhythmia originating from LV APM.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Medical Imaging Technology Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Medical Imaging Technology Year: 2020 Type: Article