The Clinical Significance of Expression of Bcl-2 and CD-44 molecules in Cervical Cancer and Its Correlation with Known Prognostic Factors / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology
;
: 2531-2535, 1999.
Article
in Korean
| WPRIM
| ID: wpr-8610
ABSTRACT
OBJECTIVE:
The study was designed to investigate the expression of Bcl-2 and CD-44 molecules in cervical cancer and compare the results with known clinical prognostic factors, and lastly to define the roles of Bcl-2 and CD-44 molecules in tumorigenesis and metastasis of cervical cancer.METHODS:
A total of 85 patients were enrolled in this study and retrospective analysis of prognostic factors were compared with immunohistochemical staining of Bcl-2 and CD-44.RESULTS:
The expression of Bcl-2 was relatively even when we compared with stage, cell types, grade and lymph node metastasis. And the CD-44 spliced variant form V6 expression was significantly strong in higher stage and positive lymph node metastasis but cell types and grade of tumor does not correlated with status of CD-44 expression.CONCLUSION:
Bcl-2 expression in cervical cancer does not correlate with clinical prognostic factors, but CD-44 spliced variant V6 form does correlated with poor prognostic factors. CD-44 may play a role in the process of the tumor metastasis and poor prognosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Uterine Cervical Neoplasms
/
Retrospective Studies
/
Genes, bcl-2
/
Carcinogenesis
/
Lymph Nodes
/
Neoplasm Metastasis
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Obstetrics and Gynecology
Year:
1999
Type:
Article
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