Impact of gestational diabetes mellitus on vascular endothelial function in pregnant women / 中国医学影像技术

ABSTRACT

Objective: To explore the impact of gestational diabetes mellitus (GDM) on vascular endothelial function in pregnant women with endothelium-dependent flow-mediated dilatation (FMD) technology, and to observe the clinical value of FMD. Methods: Totally 29 pregnant women with GDM (observation group) and 34 normal pregnant women (control group) were collected. Endothelium-dependent FMD technology was used to obtain the right brachial artery FMD value before pregnancy, on the metaphase of pregnancy and 12 weeks postpartum. Clinical data, including pregnant women's age, heart rate, body mass index, systolic blood pressure, diastolic blood pressure, total cholesterol, triglyceride and oral glucose tolerance test (OGTT) results were recorded and compared between 2 groups. FMD values were analyzed between groups and within group at different time points, and the impact factors of FMD values were explored. Results: FMD values showed first downward and then rising trend in both 2groups. Statistical differences of FMD values were found between observation group (F=85.50) and control group (F=89.59) at all 3 time points (all P0.05), while FMD of metaphase pregnancy (F=16.88) and 12 weeks postpartum (F=60.83) in control group were both larger than in observation group (both P<0.05).Blood glucose 2 hours after taking sugar and diastolic blood pressure had obvious impact on FMD value. Conclusion: GDM may lead to irreversible vascular endothelial dysfunction in pregnant women. Using FMD technology can noninvasively evaluate vascular endothelial function of GDM, which is expected to provide a new way for screening postpartum cardiovascular and cerebrovascular diseases in GDM pregnant women.