18F-FDG PET/CT metabolic parameters for prognosis of primary cervical cancer / 中国医学影像技术
Chinese Journal of Medical Imaging Technology
;
(12): 726-731, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-861029
ABSTRACT
Objective:
To assess the predictive value of metabolic parameters with different maximum standard intake value (SUVmax) threshold segmentations calculated from 18F-FDG PET/CT before concurrent chemoradiotherapy (CCRT) of cervical cancer.Methods:
Totally 45 patients underwent 18F-FDG PET/CT before CCRT, and SUVmax, maximum standard intake value (MTV) and metabolic tumor volume (TLG) were recorded. MTV and TLG were automatically segmented using different percentage SUVmax threshold segmentations (10%-85%, increased by 5%). Receiver operating characteristic (ROC) curve analysis was performed in order to obtain the cut-off values of MTV and TLG. Kaplan-Meier method was used for survival analysis.Results:
SUVmax, MTV10%, MTV75%-MTV85% and TLG75%-TLG85% were not significantly different (all P>0.05), whereas significant differences of MTV15%-MTV70% and TLG10%-TLG70%were found between 2 groups (all P<0.05). 40%SUVmax had the strongest prediction capability for prognosis. Based on ROC curve analysis, the cut-off value of MTV40% was 21.09, with sensitivity of 78.60%, specificity of 87.10% and AUC of 0.823, while the cut-off value of TLG40% was 136.71, with sensitivity of 78.60%, specificity of 77.40% and AUC of 0.788.Conclusion:
MTV40% and TLG40% calculated from 18F-FDG PET/CT can be taken as prognostic indicators for cervical cancer after CCRT.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of Medical Imaging Technology
Year:
2020
Type:
Article
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