MRI measurement of occipital lobe volume in different genders of healthy Han Chinese adults / 中国医学影像技术

ABSTRACT

Objective: To measure the occipital lobe volume in different genders of healthy Han Chinese adults with MRI. Methods: A total of 200 volunteers were selected from the healthy adult brain database of Han nationality in China. Whole-brain images were obtained using 3D magnetization prepared rapid acquisition gradient echo T1W sequence. The volume of left and right occipital lobes and whole brain volume were measured with manually sketching ROIs. Then the measured data were standardized, and the volume of left and right lateral occipital lobe were compared between different genders, the relation of the occipital lobe volume and age was analyzed, and the influence of gender and age to occipital lobe volume was analyzed. Results: The occipital lobe volume of normal adult was (105.37±10.41) cm3, which was (105.44±9.20) cm3 after standardization. Before standardization, the volume of occipital lobe in male adults ([111.34±9.15] cm3) was statistically different from that in females ([99.38±7.85]cm3), while after standardization, the volume of occipital lobe in male adults ([111.39±7.31]cm3) was also statistically different from that in females ([99.48±6.72]cm3,t=9.91, 12.01, both P0.05). Before and after standardization, no obvious correlation of occipital lobe volume with age in males or in females was observed (r=-0.01, 0.18, P=0.90, 0.08; r=0.05, 0.01,P=0.64, 0.92). There was no interaction between genders nor age on occipital lobe volume. Conclusion: The occipital lobe volume of healthy male adults is larger than that of females, and the volume of bilateral occipital lobe is basically the same in different genders. The occipital lobe volume is less likely to atrophy with age.