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Functional MRI combined with clinical prognostic factors for predicting response to concurrent chemoradiotherapy for cervical squamous cell carcinoma / 中国医学影像技术
Chinese Journal of Medical Imaging Technology ; (12): 433-438, 2020.
Article in Chinese | WPRIM | ID: wpr-861091
ABSTRACT

Objective:

To explore functional MRI combined with clinical prognostic factors (CPF) for predicting response to concurrent chemoradiotherapy (CCRT) in patients with cervical squamous cell carcinoma.

Methods:

Totally 59 patients with cervical squamous cell carcinoma who received CCRT were collected. All patients underwent diffusion weighted imaging (DMI) and dynamic contrast-enhanced MRI before and 3 months after CCRT. Then the patients were divided into non-tumor residual group (n=19) and tumor residual group (n=40) according to the

Results:

of MRI and clinical examination 3 months after CCRT, and MRI

Results:

and clinical prognostic factors (CPF) were compared between 2 groups. ROC curve of MRI parameters were drawn, AUC was calculated to evaluate the diagnostic efficacy, and the prognostic factor of CCRT for cervical squamous cell carcinoma was analyzed.

Results:

Pre-treatment maximum slope of increase (MSIL) and signal enhancement ratio (SERL) of tumor low enhancement area in tumor residual group were lower than those in non-tumor residual group (all P<0.01), while pre-treatment ADC value and the number of patients with FIGO staging and lymph node metastasis in CPF were all higher than those in non-tumor residual group (all P<0.05). The diagnostic efficacy of MSIL combined with ADC value for predicting tumor residual after CCRT was higher than that of single MRI parameter. The diagnostic efficiency was improved MRI combining multi-parameter with CPF. Pre-treatment MSIL and ADC values were independent prognostic factors for tumor residue after CCRT for cervical squamous cell carcinoma.

Conclusion:

Pre-treatment MSIL and ADC value were independent prognostic factors for tumor residue after CCRT for cervical squamous cell carcinoma. Multi-parameter MRI combined with CPF can improve diagnostic efficacy of predicting efficacy of CCRT for cervical squamous cell carcinoma.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study Language: Chinese Journal: Chinese Journal of Medical Imaging Technology Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study Language: Chinese Journal: Chinese Journal of Medical Imaging Technology Year: 2020 Type: Article