Multimodal MRI in evaluating white matter hyperintensity penumbras in patients with subcortical vascular cognitive impairment / 中国医学影像技术
Chinese Journal of Medical Imaging Technology
;
(12): 32-36, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-861105
ABSTRACT
Objective:
To explore the value of different MR techniques in evaluating white matter hyperintensity (WMH) penumbra (WMH-P) in patients with subcortical vascular cognitive impairment (SVCI).Methods:
A total of 29 SVCI patients underwent diffusion weight imaging (DTI), 3D-arterial spin labeling (3D-ASL) and chemical exchange saturation transfer amide proton transfer (CEST APT) scans as well as neuropsychological evaluation. WMH-P was defined in the range of 1 cm around WMH. Imaging parameters of WMH, WMH-P and normal appearing white matter (NAWM) outside WMH-P were measured and analyzed with cognitive scores.Results:
There were significant differences of FA and mean diffusivity MD values among WMH, WMH-P and NAWM outside WMH-P (all P<0.05), also of cerebral blood flow (CBF) between WMH-P and NAWM outside WMH-P, as well as between WMH and NAWM outside WMH-P (all P<0.05). FA value in WMH-P and NAWM outside WMH-P was positively correlated with Montreal cognitive assessment (MoCA) scores (all P<0.05).Conclusion:
3D-ASL and DTI techniques can be used to reflect the extent and progression of white matter lesions in patients with SVCI. FA value of WMH-P can well evaluate the cognitive function of SVCI patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Medical Imaging Technology
Year:
2020
Type:
Article
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