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Brain white matter changes and correlations with cognition in end-stage renal disease patients with secondary hyperparathyroidism based on local diffusion homogeneity values / 中国医学影像技术
Chinese Journal of Medical Imaging Technology ; (12): 37-41, 2020.
Article in Chinese | WPRIM | ID: wpr-861106
ABSTRACT

Objective:

To investigate the changes of white matter in patients of end-stage renal disease (ESRD) with secondary hyperparathyroidism (SHPT) by using local diffusion homogeneity (LDH).

Methods:

Fifty patients diagnosed as ESRD and underwent hemodialysis were selected. According to whether with SHPT or not, the patients were divided into SHPT group and non-SHPT group (each n=25). The cognitive function was evaluated with Montreal cognitive assessment (MoCA). Then MR plain scan was performed. The LDH value of white matter fiber in the whole brain were compared between 2 groups based on voxel.

Results:

Compared with non-SHPT group, SHPT group showed diffuse and symmetrical LDH decreased area in bilateral cerebral hemispheres, and in the focal right cerebellar hemispheres (all P0.05).

Conclusion:

LDH value can provide information of the white matter's LDH in ESRD patients with SHPT, and the changes are related to cognition and clinical indicators.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Medical Imaging Technology Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Medical Imaging Technology Year: 2020 Type: Article