Hybrid 18F-FDG PET/MR evaluation of ischemic cerebrovascular disease / 中国医学影像技术

ABSTRACT

Objective: To investigate the value of hybrid 18F-FDG PET/MR in patients with ischemic cerebrovascular disease. Methods: A total of 10 healthy volunteers and 17 patients with chronic unilateral internal carotid artery (ICA) or middle cerebral artery (MCA) occlusion underwent hybrid 18F-FDG PET/MR examination. The images were analyzed by two experienced physicians. The mean ADC value (ADCmean), mean standardized uptake value (SUVmean) and the maximum standardized uptake value (SUVmax) were analyzed between left and right brain regions of healthy volunteers. ADCmean, SUVmean and SUVmax of corresponding areas of the cerebral infarction and contralateral corresponding areas, the surrounding areas of the cerebral infarction and contralateral side of patients were also compared. Results: MRI of 10 healthy volunteers showed no abnormal performance. 18F-FDG images were clear and the metabolic distribution of each brain region was symmetrical. ADCmean, SUVmean, SUVmax were not statistically different between the left and right brain regions (all P>0.05). The cerebral infarctions were observed in MRI of 17 patients, and ADCmean, SUVmean and SUVmax significantly reduced on the affected side (all P<0.01), while ADCmean, SUVmean and SUVmax also significantly reduced in the surrounding areas of the cerebral infarction (all P<0.01). Conclusion: Hybrid 18F-FDG PET/MR examination can evaluate patients with chronic ischemic cerebrovascular disease and provide information of brain structure and brain metabolism.