Changes of quantitative parameters of dynamic contrast-enhanced MRI in normal uterus of women with different menstrual states and clinical significance / 中国医学影像技术

ABSTRACT

Objective: To investigate the changes and clinical significance of quantitative parameters of dynamic contrast-enhanced MRI in normal uterus of women during different menstrual states. Methods: Totally 46 women with different menstrual states who underwent dynamic contrast-enhanced MRI were divided into premenopausal phase (proliferative phase [n=16], secretory phase [n=16]) and postmenopausal phase (n=14) according to different menstrual states. The quantitative parameters (Ktrans, Kep and Ve) of endometrium, junctional zone and myometrium were measured. One-way ANOVA or rank sum test was used to compare the quantitative parameters with different uterus structures and menstrual states. Results: The Ktrans value and Kep value of endometrium between the same menstrual states were statistically significant (all P<0.05). There were significant differences of Ktrans, Kep, in secretory phase, proliferative phase and postmenopausal phase, Kep in secretory phase and proliferative phase (P<0.05). There was statistically significant difference of Ve in junctional zone between proliferative phase and postmenopausal phase (P<0.05). There were significant differences in Ktrans, Kep and Ve among endometrium, junctional zone and myometrium under the same menstrual state (all P<0.05). The Ktrans was statistically significant during the secretory phase (all P<0.05). There was no significant difference in Kep between the junctional zone and the myometrium except postmenopausal phase, and the Kep were statistically significant between the structures in different menstrual states (P<0.05). Conclusion: The changes of Ktrans, Kep and Ve in different menstrual states should be considered when using the quantitative parameters of dynamic enhanced MRI to evaluate uterine diseases.