Analysis of correlation of blood lipid and lumbar spine bone mineral density with different genders based on quantitative CT / 中国医学影像技术

ABSTRACT

Objective: To analyze the correlation between lumbar spine bone mineral density (BMD) and blood lipids in different genders by measuring lumbar spine BMD using quantitative CT (QCT). Methods: Totally 670 subjects who underwent physical examinations were enrolled, including 341 males and 329 females, and their body mass index (BMI) were calculated. Fasting venous blood test for total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were performed. QCT was used to measure lumbar spine BMD. According to the results, the subjects were then divided into normal bone mass group, bone mass reduction group and osteoporosis group for each gender, and the differences of lumbar spine BMD of 3 groups for different genders and the correlation between lumbar spine BMD and various lipid parameters were analyzed. Taken lumbar spine BMD as the dependent variable, the parameters with statistically significant differences of male and female as independent variables, multiple linear regression analysis was performed. Results: In males, TC and LDL-C in the bone mass reduction group were higher than those in the normal bone mass group (both P<0.05). In females, TC in the osteoporosis group and the bone mass reduction group were higher than that in normal bone mass group, and LDL-C in the bone mass reduction group was higher than that in normal bone mass group (all P<0.05). There was negative correlation between BMD and age, BMI and HDL-C in males (all P<0.05). Female lumbar spine BMD was negatively correlated with age, TC, TG and LDL-C (all P<0.05). Multiple linear regression results showed that age was a risk factor for the decline of lumbar spine BMD in middle-aged and elderly people. Conclusion: There is correlation between dyslipidemia and the decrease of lumbar spine BMD in middle-aged and elderly people. Age is a risk factor for the decrease of lumbar spine BMD in middle-aged and elderly people.