18F-FDG PET glucose metabolism imaging and MRI in patients with hypertrophic cardiomyopathy / 中国医学影像技术

ABSTRACT

Objective: To assess the changes of glucose metabolism in hypertrophic cardiomyopathy (HCM) patients with 18F-FDG PET in fasting and glucose-loading states. Methods Totally 36 patients with HCM underwent cardiac MRI (CMRI) and twice 18F-FDG PET, once in fasting state and once during glucose load state. Semiquantified assessment of metabolism score to PET images was analyzed. According to the delay enhancement (DE) on CMRI, HCM patients were divided into DE-positive group (n=24) and DE-negative group (n=12). Then the difference of semiquantified scores was compared. Results In fasting state, patients in DE-positive group had lower summed metabolism scores than those in DE-negative group (23.73±7.02 vs 36.24±14.18, P=0.015), while there was no significant difference in glucose-loading state (6.25±10.63 vs 4.38±7.41, P=0.099). Totally 11 patients had 42 myocardial segments which were normal or with improved uptake in fasting state, but defected or sparse during glucose load state. Compared with other 25 patients, these 11 patients had greater left ventricular wall thickness and greater left ventricular posterior wall thickness, more segments with DE and lower left ventricular ejection fraction (all P<0.05). Conclusion 18F-FDG PET myocardial glucose metabolism imaging in HCM patients in fasting state and during glucose load state shows obvious heterogeneity. Combined with CMRI, it may be used as an indicator of risk stratification in patients with HCM.