One-stop CT gemstone spectral and perfusion imaging for prediction in rabbit axillary lymph nodes / 中国医学影像技术

ABSTRACT

Objective: To explore the application value of one-stop CT gemstone spectral and perfusion imaging quantitative parameters in predicting the properties of axillary lymph nodes. Methods Totally 60 purebred female New Zealand white rabbits were randomly divided into two groups, and rabbit models of axillary metastatic lymph nodes with VX2 implanted breast cancer (metastasis group) and inflammatory lymph nodes (inflammation group) were established, respectively. One-stop CT gemstone spectral and perfusion imaging scan was performed at the end of the fourth week after modeling. Then the axillary lymph nodes were taken for pathological examination and compared with CT images. Two independent samples t-test were used to compare the energy parameters and perfusion parameters between metastatic and inflammatory lymph nodes. Logistic regression and ROC curves were used to analyze the efficacy of single parameters and combined parameters in diagnosis of rabbit axillary lymph nodes. Results The blood flow (BF), blood volume (BV), arteriovenous iodine concentration (IC), standardized iodine value (NIC) and the slope (λ) of the energy spectrum curve from 40 keV to 70 keV in the metastasis group were higher than those in inflammation group (all P0.05). Taken 0.65 as the threshold, AUC of combined parameters (BF+arterial phase λ+venous phase λ) was 0.942, the sensitivity, specificity, positive predictive value and negative predictive value in diagnosis of axillary lympy nodes were 79.68%, 95.92%, 92.91% and 82.70%, respectively. Conclusion: The quantitative parameters of one-stop CT gemstone spectral and perfusion imaging show good diagnostic efficacy in identifying rabbit axillary breast cancer metastatic lymph nodes and inflammatory lymph nodes, while combined parameters (BF+arterial phase λ+venous phase λ) have higher diagnostic value.