DWI and minimum ADC value in differential diagnosis of intracranial anaplastic ependymomas from ependymomas in children / 中国医学影像技术

ABSTRACT

Objective To investigate the value of DWI and minimum ADC value differential diagnosis of intracranial anaplastic ependymomas from ependymomas in children. Methods MRI data of 22 children with ependymoma (n=8) or anaplastic ependymoma (n=14) confirmed by operation and pathology were retrospectively analyzed. All patients underwent plain and enhanced MR scanning and DWI before operation. The minimum ADC value of parenchymal part of the tumors were measured and compared between children with ependymoma and anaplastic ependymoma. Then ROC curve was used to identify the diagnostic efficacy of minimum ADC value. Results The minimum ADC value of anaplastic ependymoma was (0.579±0.245)×10-3 mm2/s, while of ependymoma was (0.943±0.128)×10-3 mm2/s. The difference was statistically significant (t=3.881, P=0.001). The AUC of ROC curve was of 0.884 (P=0.003). Taken minimum ADC value=0.695×10-3 mm2/s as the threshold, the sensitivity was 100%, and the specificity was 71.4%. Conclusion The minimum ADC value has high clinical value in differential diagnosis of intracranial ependymoma and anaplastic ependymoma in children, which can be used as an effective supplement for routine MRI.