Effects of whole- course MDT nutrition management on radiotherapy in elderly patients with esophageal cancer / 中国肿瘤临床

ABSTRACT

Objective: To explore the effect of MDT nutrition management on the radiotherapy process of elderly patients with esophageal cancer. Methods: From January 2018 to September 2019, 60 elderly patients with esophageal squamous cell carcinoma were selected, and randomly divided into the control group (Group A, 30 cases) and the experimental group (Group B, 30 cases). All the groups received radiotherapy in The First Hospital of Shanxi Medical Univesity. The Group A was treated with routine nutrition intervention and the Group B with multidisciplinary team (MDT) nutrition intervention. Body mass index (BMI), nutritional status, the incidence of adverse reactions and treatment time were eraluated respectively. Results: The patient-generated subjective global assessment (PG-SGA) score and the incidence of moderate to severe malnutrition in Group A (86.3%) were significantly higher than those in Group B (70%); the PG-SGA score after radiotherapy was higher than that before radiotherapy in both groups, and it was evidently higher in Group A (P<0.05). Total protein (TP), albumin (ALB) and prealbumin (PA) decreased first and then increased in Group A, but they increased steadily or gradually in Group B. WBC and Hb decreased significantly in Group A compared with those in Group B (P< 0.05). In comparison with Group A, the levels of ALB, PA, TP and BMI in Group B were increased after radiotherapy (P<0.05), the incidence of acute mucosal reaction above grade II (13.3%) and myelosuppression (26.3%) was lower (P<0.05), the quality of life was better (P<0.05) and the total treatment time was shorter [(41.97±2.59) d] (P<0.05). Conclusions: The total course of MDT nutrition management significantly improved malnutrition, reduced the incidence of adverse reactions and total treatment time, and improved the quality of life.