Analysis of prognostic and risk factors during the early relapse/progression of follicular lymphoma / 中国肿瘤临床

ABSTRACT

Objective: To investigate the incidence, prognostic value, and risk factors associated with progression of disease within 24 months (POD24) in patients with follicular lymphoma (FL). Methods: In Tianjin Medical University Cancer Institute and Hospital from January 2010 to December 2015,the clinical and follow-up data of 140 patients who were newly diagnosed with FL and received chemotherapy was collected.The expression levels of Myc, Bcl-2, Bcl-6, P53, CD10,MUM-1, and Ki-67 in tumor tissues from 75 patients before treatment were assessed with immunohistochemical (IHC) staining. Kaplan-Meier method and Cox regression model were applied to evaluate the effect of POD24 on the prognosis of FL. Logistic analysis was performed to identify the risk factors associated with POD24. Results: Among the 140 patients newly diagnosed with FL, 42 (30%) patients showed POD24. The results of Kaplan-Meier analysis revealed that patients with POD24 showed significantly reduced overall survival (OS) compared with patients without POD24 (Pupper limit of normal, high Ki-67 expression, and positive MUM-1 expression were risk factors associated with POD24 (all Pupper limit of normal, high Ki-67 expression, and positive MUM-1 expression were risk factors associated with POD24. Moreover, FLIPI ≥3 and positive MUM-1 expression were independent risk factors associated with POD24. The sensitivity and accuracy of FLIPI combined with MUM-1 (FLIPI-M) in predicting POD24 were higher than that of FLIPI alone, and thus have high value in clinical practice.