Advances in chronic liver diseases with abnormal chemokine expression and colorectal cancer liver metastasis / 中国肿瘤临床

ABSTRACT

The incidence of colorectal cancer (CRC) is increasing rapidly in China. In fact, in 2019, China was the country with the highest CRC case numbers in the world. Specific myeloid cell subsets are recruited into the liver micro-environment via chemokine-receptor axis and facilitate the progression of colorectal liver metastasis(CRLM). In China, many CRC patients suffer concomitant chronic liver diseases, such as chronic hepatitis B (CHB), nonalcoholic fatty liver disease (NAFLD), and alcoholic liver disease (ALD). Aberrant expression of chemokines is observed in these chronic liver diseases, and some of them have been associated with cancer metastasis. Here, first, we review the recent epidemiological trends of CRC, CHB, NAFLD, and ALD in China, briefly summarizing the abnormal chemokine changes in these chronic liver diseases. Furthermore, we review the potential mechanisms that may explain how different chronic liver diseases facilitate CRLM, focusing on the chemokine-myeloid cell subsets axis, which has been previously reported to be related to CRLM.