Advances in the treatment for blast phase myeloproliferative neoplasm / 中国肿瘤临床
Chinese Journal of Clinical Oncology
;
(24): 736-740, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-861646
ABSTRACT
Blast phase myeloproliferative neoplasm (MPN-BP) represent a type of secondary acute leukemia and are associated with a poor patient prognosis worldwide. Currently, there is no standardized treatment regimen for MPN-BPs, and treatment remains a major clinical challenge. In recent years, significant progress has been made in understanding the biological mechanisms of MPNs, especially the abnormal activation of the JAK-STAT signaling pathway caused by driver gene mutations; this has opened up a new avenue in exploring the mechanism and treatment of MPN-BP. However, in terms of disease pathogenesis, MPN-BP are different from primary acute leukemia, and different therapeutic strategies for MPN-BP have also been investigated. This article focuses on the advances made in MPN-BP treatment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Clinical Oncology
Year:
2021
Type:
Article
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