Endoscopic Features and Clinical Pathology Analysis of Gastric Mucosa-associated Lymphoid Tissue Lymphoma / 胃肠病学

ABSTRACT

Background: Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is a rare extranodal B cell lymphoma with atypical clinical symptoms and diverse endoscopic manifestations, and its diagnosis is a challenging. Aims: To summarize the clinicopathological features and endoscopic manifestations of gastric MALT lymphoma. Methods: Clinicopathological data of 33 patients with gastric MALT lymphoma diagnosed by pathology from Jan.2013 to Dec.2018 at the Affiliated Hospital of Qingdao University were retrospectively analyzed. The clinicopathological features and endoscopic manifestations of gastric MALT lymphoma were summarized. Results: The incidence of gastric MALT lymphoma of male was slightly higher than that of female, and the average age was 54 years old. The infection rate of Helicobacter pylori (Hp) was 81.8%. The main clinical manifestation was upper abdominal pain (48.5%). Gastric body was the main lesion site. The endoscopic morphology was dominated by ulcer type. Twenty-six patients were early gastric MALT lymphoma (Ⅰ+Ⅱ), and 7 were advanced gastric MALT lymphoma (Ⅲ+Ⅳ). Ki-67 proliferation index in early gastric MALT lymphoma was significantly lower than in advanced gastric MALT lymphoma (P0.05). Conclusions: The clinical manifestations of gastric MALT lymphoma are not typical, and the endoscopic manifestations are varied. Endoscopic examination combined with pathological biopsy is the basis of diagnosis. Regular endoscopic follow-up is very important for the prognosis of patients with gastric MALT lymphoma.