Pathological Changes and Influencing Factors of Lamb's Tripe Extract and Vitamin B12 Capsule in Treatment of Chronic Atrophic Gastritis With Intestinal Metaplasia / 胃肠病学

ABSTRACT

Background: Chronic atrophic gastritis with intestinal metaplasia is closely related to the development of gastric cancer. Studies have showed that Lamb's Tripe Extract and Vitamin B12 capsule (LTEVB12) may reverse atrophy and intestinal metaplasia by promoting gastric mucosal gland proliferation, inhibiting gland apoptosis and inhibiting oxidative stress response in rats.Aims: To explore the pathological changes and influencing factors of LTEVB12 in treatment of chronic atrophic gastritis with intestinal metaplasia. Methods: A total of 173 patients with chronic atrophic gastritis with intestinal metathesis from June 2018 to June 2019 at Xijing Hospital were enrolled. All patients were treated with LTEVB12 (2 capsules tid). Gastroscopy and gastric mucosal biopsies were performed at 6 months and 12 months after treatment. The therapeutic effect of the drug was evaluated according to the changes of OLGA staging and OLGIM staging before and after treatment. The influencing factors were analyzed by univariate analysis and multivariate analysis. Results: After 6 months of treatment, the effective rates on OLGA staging and OLGIM staging were 49.7% and 32.9%, respectively. After 12 months of treatment, the effective rates on OLGA staging and OLGIM staging were 56.4% and 41.8%, respectively. The total effective rates of 6 months and 12 months treatment were 64.7% and 70.9%, respectively. Univariate analysis showed that education, fried food, statins and antibiotics were correlated with OLGA staging, while age was correlated with OLGIM staging. Multivariate analysis showed that education, fried food and antibiotics were independent factors of OLGA staging. Conclusions: LTEVB12 can significantly reduce the OLGA staging and OLGIM staging in patients with chronic atrophic gastritis with intestinal metaplasia, which suggests that LTEVB12 has the potential to reduce risk of gastric cancer and has the prospects of clinical application in prevention of gastric cancer.