Recurrence of Helicobacter pylori Infection After Eradication and its Influencing Factors / 胃肠病学

ABSTRACT

Background: Helicobacter pylori (Hp) is a Gram-negative bacterium that colonized the human gastric mucosa. Hp infection is closely related with a variety of digestive diseases and there is the possibility of recurrence after eradication. Aims: To investigate the recurrence of Hp infection after eradication and its influencing factors. Methods: Clinical data of 317 patients with Hp infection from January 2015 to July 2018 at Daping Hospital, Army Military Medical University were retrospectively analyzed. The recurrence of Hp infection after eradication was recorded. The influencing factors of recurrence were analyzed by univariate analysis and multivariate Logistic regression analysis. Results: Twenty-five patients had recurrence of Hp infection, the recurrence rate was 7.9%. Among them, 10 patients relapsed in the first year, 11 patients in two years, and 4 patients relapsed after more than two years. The recurrence rate of clarithromycin+tinidazole-containing regimen was the highest (37.5%), while the recurrence rate of amoxicillin+PPI-containing modified dual regimen was the lowest (3.4%). Univariate and multivariate Logistic regression analysis showed that more family members, peptic ulcer and receiving gastroscopy examination after eradication were the independent risk factors for Hp infection recurrence (P<0.05). Conclusions: More family members, peptic ulcer and receiving gastroscopy examination after eradication are the risk factors for recurrence of Hp infection. For patients with high risk of Hp recurrence, regimen with high eradication rate should be carefully selected and the follow-up examination should be strengthened.