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Research Progress on Pathogenesis of Hepatic Encephalopathy / 胃肠病学
Chinese Journal of Gastroenterology ; (12): 116-120, 2020.
Article in Chinese | WPRIM | ID: wpr-861719
ABSTRACT
Hepatic encephalopathy (HE) is a kind of neuropsychiatric syndrome basing on metabolic disorder caused by acute or chronic liver dysfunction or abnormal portosystemic shunt. It is one of the common complications and causes of death in various end-stage liver diseases. The clinical manifestations of patients with HE can vary from personality changes, behavior abnormalities to disturbance of consciousness and coma. The pathogenesis of HE is complex. Theories about ammonia neurotoxicity and alterations in neurotransmitters have been widely accepted. Roles of inflammation, gut microbiota, premature astrocyte senescence, impaired cerebral microcirculation, hemichannel dysfunction, and bile acid also attract much attention. In this review article, the research progress on pathogenesis of HE was briefly summarized.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Etiology study Language: Chinese Journal: Chinese Journal of Gastroenterology Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Etiology study Language: Chinese Journal: Chinese Journal of Gastroenterology Year: 2020 Type: Article