Application of Domestic Made High Definition Magnifying Gastroscope for Gastric Flat Lesions / 胃肠病学

ABSTRACT

Background: Gastroscopy is an effective method for screening early gastric cancer (EGC), which is mainly relied on expensive imported endoscopic equipment. Aims: To evaluate the performance of domestic made high definition magnifying gastroscopy for diagnosis of gastric flat lesions. Methods: A total of 99 patients with focal flat gastric mucosal lesions detected by conventional white-light endoscopy at Shanghai Renji Hospital from Jan. 2018 to Dec. 2018 were enrolled. Magnifying gastroscopy was performed using domestic made AOHUA AQ-200 endoscopic system. Nature of the lesion was assessed according to VS classification. Using pathological diagnosis as gold standard, the diagnostic performance of the domestic made gastroscopy for gastric flat lesions was evaluated, and the consistency of endoscopic and pathological results was analyzed. Results: The sensitivity, specificity and accuracy of domestic made high definition magnifying gastroscopy for diagnosis of EGC/precancerous lesions were 92.9%, 98.8% and 98.0%, respectively; the positive predictive value and negative predictive value were 92.9% and 98.8%, respectively. The endoscopic diagnosis was highly consistent with the pathological results with a kappa value of 0.917. The incidence of demarcation line, irregular or disappeared microvascular morphology, and irregular or disappeared microsurface glandular structure in EGC/precancerous lesions was significantly higher than those in non-EGC/precancerous lesions (P<0.05). Conclusions: Domestic made high definition magnifying gastroscope can meet the requirements of endoscopic diagnosis and treatment, which allows the primary care institutions to carry out the job of screening, diagnosis and treatment of EGC.