Effect of Exogenous Vitamin D on Intestinal Mucosal Barrier and Inflammatory Factors in Patients / 胃肠病学

ABSTRACT

Background: Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory disease with unknown etiology. Studies have shown that vitamin D level is reduced in patients with IBD, and oral supplementation of vitamin D3 can significantly reduce the risk of IBD. However, its specific mechanism is still unclear. Aims: To explore the effect of exogenous vitamin D on intestinal mucosal barrier and inflammatory factors in patients with IBD. Methods: A total of 198 patients with IBD from January 2016 to December 2018 at Naijing Lishui People's Hospital were enrolled, and 195 healthy subjects were served as normal controls. IBD patients were randomly divided into observation group and control group. Patients in the control group received routine therapy, while patients in the observation group received exogenous vitamin D in addition to routine therapy. The serum levels of 25(OH)D3, diamine oxidase (DAO), D-lactic acid, endotoxin, and inflammatory factors IL-1β, IL-6, CRP, TNF-α were determined. Results: Serum 25(OH)D3 level in healthy control group was significantly higher than that in IBD group (P0.05). Before treatment, no significant differences in levels of DAO, D-lactic acid, endotoxin and inflammatory factors IL-1β, IL-6, CRP, TNF-α were found between observation group and control group (P>0.05). After treatment, the levels of DAO, D-lactic acid, endotoxin, IL-1β, IL-6, CRP and TNF-α in observation group were significantly decreased than those in the control group (P<0.05). Conclusions: IBD patients have obvious vitamin D deficiency. Supplementation of exogenous vitamin D can reduce inflammatory factor levels and improve intestinal mucosal barrier function.