Risk Factors of Gastric Mucosal Intestinal Metaplasia: Gastroscopy and Pathological Analysis of 60 386 Cases / 胃肠病学

ABSTRACT

Background: Gastric mucosal intestinal metaplasia is one of the pathological manifestations of chronic atrophic gastritis. Early intervention of risk factors contributes to inhibiting the progression of atrophic gastritis to gastric cancer. Aims: To investigate the risk factors of gastric mucosal intestinal metaplasia. Methods: Results of gastroscopy and pathology of 60 386 patients from Jan. 2013 to Sept. 2018 at Shanghai General Hospital were collected. Logistic regression analysis was used to analyze the influencing factors of gastric mucosal intestinal metaplasia. Results: Gastric mucosal intestinal metaplasia was found in 15 318 (25.4%) patients, while bile reflux was found in 6 218 (10.3%) patients. Univariate Logistic regression analysis showed that gender, age, bile reflux and Hp infection were influencing factors of gastric mucosal intestinal metaplasia (P<0.05). Multivariate Logistic regression analysis showed that bile reflux had no effect on gastric mucosal intestinal metaplasia (OR=1.04, 95% CI 0.97-1.11, P=0.25), however, gender (OR=1.13, 95% CI 1.08-1.17, P<0.01), age (OR=1.59, 95% CI 1.56-1.61, P<0.01) and Hp infection (OR=1.25, 95% CI 1.19-1.31, P<0.01) were risk factors of gastric mucosal intestinal metaplasia. Conclusions: Gender, age and Hp infection are risk factors of gastric mucosal intestinal metaplasia. Bile reflux cannot be considered as the influencing factor of intestinal metaplasia of gastric mucosa.