Effect of Endoscopic Mucosal Resection on Erythrocyte Immune Function and Inflammatory Cytokines in Patients With Gastrointestinal Polyps / 胃肠病学

ABSTRACT

Background: Trauma induced by endoscopic surgery may inhibit erythrocyte immune function and activate inflammatory responses, however, there are certain differences between different surgical methods. Aims: To investigate the effect of endoscopic mucosal resection (EMR) on erythrocyte immune function and inflammatory cytokines in patients with gastrointestinal polyps. Methods: A total of 315 patients with gastrointestinal polyps in Meishan People's Hospital from Jan. 2011 to Dec. 2016 were collected and randomly allocated into EMR group (n=160) and control group (n=155), and underwent EMR and routine endoscopic electrocoagulation resection, respectively. The resection rate, postoperative erythrocyte immune function, including peripheral blood red-cell membrane complement 3b receptor rosette (C3bRR), immune complex rosette (ICR), CD58 and CD59, as well as serum inflammatory cytokines, including interleukin-1β (IL-1β), IL-6, IL-8 and IL-12 were compared between the two groups. Results: All gastrointestinal polyps were removed successfully in both groups. Less intraoperative complications were observed in EMR group than in control group (3.1% vs. 20.0%, P<0.05). The postoperative levels of C3bRR, CD58 and CD59 on red-cell membrane in EMR group were significantly higher than those in control group (P<0.05), while the postoperative levels of ICR, and serum IL-1β, IL-6, IL-8 and IL-12 were significantly lower in EMR group than in control group (P<0.05). Conclusions: EMR is effective for treatment of gastrointestinal polyps with lower intraoperative complications. Furthermore, it may protect the erythrocyte immune function and suppress the inflammatory responses caused by surgery.