Retrospective Analysis of Enteral Nutrition Support in Patients With Moderate to Severe Ulcerative Colitis / 胃肠病学

ABSTRACT

Enteral nutrition (EN) can promote intestinal mucosal healing, and has some therapeutic value in patients with Crohn's disease (CD). However, studies on application and efficacy of EN in patients with ulcerative colitis (UC) are rare. Aims: To investigate the therapeutic effect of EN in patients with moderate to severe active UC who have nutritional risk. Methods: A total of 90 moderate to severe UC patients with nutritional risk from January 2016 to January 2018 at the First People's Hospital of Qujing and First Affiliated Hospital of Kunming Medical University were enrolled, and were divided into EN group and non-EN group. Mayo score, body mass index (BMI) and levels of hemoglobin (HGB), albumin (ALB) and total protein (TP) before and after treatment in EN group and non-EN group were analyzed. Results: There were no significant differences in Mayo score, BMI, HGB, ALB and TP between the two groups before treatment (P>0.05). After treatment, Mayo score was significantly decreased (P<0.05), and ALB, TP were significantly increased in EN group (P<0.05); while Mayo score, BMI were significantly decreased in non-EN group (P<0.05). After treatment, BMI, ALB, TP were significantly higher in EN group than in non-EN group (P<0.05). Conclusions: EN can effectively improve the nutritional status of patients with UC and play an auxiliary role in improving the disease.