Analysis of Antibiotic Resistance of Helicobacter pylori Isolates in Changchun Area / 胃肠病学

ABSTRACT

Background: Due to unrational use of antibiotics in clinical practice, the resistance rate of Helicobacter pylori (Hp) has increased year by year. The drug resistance rate is different in different regions. Aims: To investigate the resistance of Hp to seven commonly used antibiotics in Changchun area, and provide the theoretical guidance for clinical treatment of Hp infection. Methods: The gastric mucosal specimens of 298 patients undergone gastroscopy from Sept. 2014 to Oct. 2017 at the First Hospital of Jilin University were collected. Hp was isolated and identified. The antibiotic sensitivity of Hp was detected by agar dilution method. Results: A total of 69 Hp strains were successfully isolated from 298 gastric mucosal specimens, the isolation rate was 23.1%. The susceptibility test results showed that the resistance rate of clarithromycin was the highest among the 69 strains (52.2%), the lowest was the resistance rate to amoxicillin (5.8%). Seventeen (24.6%) strains were sensitive to the seven antibiotics, 16 (23.2%) strains were resistant to one antibiotic, and 36 (52.2%) strains were resistant to more than two antibiotics. Conclusions: Hp in this region is highly resistant to clarithromycin and nitrooxazoles. Amoxicillin can be recommended as a treatment for eradication of Hp infection.