Risk Factors of Helicobacter pylori Re-infection After Eradication / 胃肠病学

ABSTRACT

Background: Helicobacter pylori (Hp) is one of the most prevalent chronic pathogens in the world. It is easily to recur after eradication treatment. Aims: To investigate the risk factors of Hp re-infection after eradication. Methods: A prospective cohort study was performed from January 2012 and January 2014 at Hospital of 75600 PLA Troops with 803 patients of Hp infection diagnosed by 14C-urea breath test. All patients were followed up for 3 years after successful eradication of Hp infection. Hp re-infection was recorded during the follow-up. The risk factors of Hp re-infection were analyzed by univariate and multivariate Logistic regression analysis. Results: A total of 721 patients finished the 3 year follow-up. Hp re-infection rate was 8.7%. Univariate and multivariate Logistic regression analysis showed that age, peptic ulcer, periodontitis, and long-term use of antibiotics were independent risk factors of Hp re-infection, and fermented dairy products, fruits and vegetables were protective factors for Hp re-infection. Conclusions: After Hp eradication, there still has the risk of re-infection, risk factors should be positively controlled in clinic, thereby reducing the risk of Hp re-infection.