Role of KIAA1199 Gene in Digestive System Neoplasms / 胃肠病学

ABSTRACT

KIAA1199 gene is an important member of the HUGE database, and is involved in the transduction of intracellular signaling pathway through epigenetic mechanism, regulating the cell growth, differentiation, apoptosis and migration. Recent studies showed that KIAA1199 gene is closely related to tumorigenesis and tumor development. The expression of KIAA1199 gene is highly upregulated in many types of tumor, especially in digestive system neoplasms, and having the effects of promoting proliferation, adhesion, invasion and migration of tumor cells. This article reviewed the role of KIAA1199 gene in digestive system neoplasms.