Comparison on therapeutic effect of stent implantation and drug treatment for young cerebral infarction combined with middle cerebral artery stenosis / 中国介入影像与治疗学

ABSTRACT

Objective: To compare the effect of stent implantation and drug treatment for young cerebral infarction combined with middle cerebral artery stenosis. Methods: A total of 71 young cerebral infarction patients (aged 30-44 years) with severe stenosis of middle cerebral artery (stenosis rate >70%) were enrolled and divided into drug group (n=39, received conventional oral medication) and stent group (n=32, underwent stent implantation). The therapeutic effects and follow-up outcomes during 24 months were compared between 2 groups. Results: The success rate of stent group was 100%, and 32 stents were implanted. Significant differences were found between the scores at enrollment and those at 3, 6, 12 and 24 months of modified Rankin scale (mRS) and National Institutes of Health Stroke Scale (NIHSS) within both the two groups during the follow-up (all P0.05). Within 24 months' follow-up, the incidence of end-point event was 20. 51% (8/39), the stroke recurrence rate was 20.51% (8/39), and the disability rate of recurrence stroke (mRS score ≥ 2 points) was 20. 51% (8/39) in drug group, while in stent group was 6.25% (2/32), 3.13% (1/32) and 3.13% (1/32), respectively. There was no statistically significant difference of the incidence of endpoint events between 2 groups (P=0.17), while the recurrence rate of stroke (P=0.04) and the disability rate of recurrent stroke (P=0.04) in stent group were both lower than those in drug group. Conclusion: Compared with drug therapy, stent implantation can reduce stroke recurrence rate and disability rate of in young cerebral infarction with middle cerebral artery stenosis.