Clinical efficacy of microwave ablation in treatment of secondary hyperparathyroidism ineligible for surgical resection / 中国介入影像与治疗学

ABSTRACT

Objective: To observe the efficacy and safety of microwave ablation (MWA) in treatment of secondary hyperparathyroidism (SHPT) ineligible for surgical resection. Methods: Clinical data of 51 patients with SHPT ineligible for surgical resection who underwent MWA were retrospectively analyzed. The maximum diameter of single proliferative nodule, serum intact parathyroid hormone (iPTH), calcium and phosphorus were assessed and compared before and after ablation. The complications, local recurrence rate and new incidence rate were counted during follow-up. Results: Totally 83 parathyroid hyperplasia nodules in 51 SHPT patients were completely ablated at one time. Three, 6 months after MWA and at the end of the follow-up, the maximum diameter of single proliferative nodule was all smaller than that before MWA (all P<0.05), and serum iPTH, calcium, and phosphorus levels were all lower than that before MWA (all P<0.05). During follow-up, 9 patients (9/51, 17.65%) had minor complications related to MWA, while no serious complication occurred. At the end of follow-up, the local recurrence rate was 5.88% (3/51) and the new incidence rate was 7.84% (4/51). Conclusion: MWA is safe and effective in treatment of SHPT ineligible for surgical resection.