Application and dosimetry analysis of 3D printing non-coplanar template assisted CT-guided radioactive seed implantation / 中国介入影像与治疗学

ABSTRACT

Objective: To explore the application value of 3D-printing non-coplanar template (3D-PNCT) assisted CT-guided 125I seed implantation through dosimetry analysis. Methods: A total of 15 patients underwent 3D-PNCT assisted CT-guided 125I seed implantation. Posture fixation and set-up were performed with CT-simulator devices. Before operation, pre-plan was carried out, and 3D-PNCT was printed. 125I seeds were implanted into the lesions according to pre-plan after set-up and following postoperative verification. The dosimetric parameters, including doses of pre-plan and post-operation 90%, 100% target volume (D90, D100) and volume percent of 90%, 100%, 150% prescribed doses (V90, V100, V150) were compared. Results: 3D-PNCT assisted CT-guided 125I seed implantation were successfully accomplished in 18 lesions of all 15 patients. The median time of 3D-PNCT set-up was (11.62±2.57)min. Post-operation gross tumor volume (GTV) was more than that in pre-plan ([64.25±50.16]cm3 vs [57.37±44.25]cm3; t=-3.163, P=0.006). The number of implantated seeds were more than that in pre-plan (46.39±24.18 vs 43.78±21.63; t=-2.636, P=0.017). Post-operation V100 and V150 were less than those in pre-plan (both P0.05). Conclusion: 3D-PNCT set-up can be quickly and precisely accomplished using CT-simulator devices. 3D-PNCT assisted CT-guided 125I seed implantation can accurately performed through well match of post-operation main dosimetric parameters with those in pre-plan.