Nanocomposites combined with molecular imaging in hyperthermia and its application of oral squamous cell carcinoma / 中国介入影像与治疗学

ABSTRACT

Tumor hyperthermia has become a new method of nanomedical therapy with low toxicity and high cure rate in recent years. Local hyperthermia, especially combined with surgery, radiotherapy or chemotherapy, is effective in the treatment of malignant tumors, such as oral squamous cell carcinoma, but still has some problems in following fields,included the control of heat dose, the screening of targeted therapeutic area, the differentiation of normal cells from cancer cells and so on. With the development of nanotechnology, multifunctional nano-composites have been introduced into the local hyperthermia of head and neck cancer. Targeting cancer cells with molecular imaging and simultaneous therapy through local hyperthermia can effectively improve the accuracy of treatment, and prolong the survival of patients. The advancements of nano-composites combined with molecular imaging technology and the application for tracking oral squamous cell carcinoma in hyperthermia were reviewed in this article.