Mean platelet volume combined with Gensini score in prediction of short-term prognosis in patients with acute ST segment elevation myocardial infarction after emergency percutaneous coronary intervention / 中国介入影像与治疗学

ABSTRACT

Objective To investigate the value of mean platelet volume (MPV) combined with Gensini score in predicting short-term prognosis of patients with acute ST-segment elevation myocardial infarction (STEMI) after emergency percutaneous coronary intervention (PCI). Methods A total of 186 patients with STEMI who underwent emergency PCI were enrolled. The relevant laboratory tests were completed before PCI, and MPV was detected. Gensini score was obtained according to the results of coronary angiography. The occurrence of major adverse cardiovascular events (MACE) after PCI was recorded. Then statistical analysis was performed. Results There were 36 patients with MACE after PCI (MACE group) and 150 patients without MACE (non-MACE group). The total cholesterol (TC), platelet count (Plt), D-dimer, N-terminal pro-brain natriuretic peptide (NT-proBNP), MPV, Gensini score and the proportion of lesions involving three vessels of coronary arteries were statistically different between the two groups (all P<0.05). MPV, Gensini score, Plt, NT-proBNP and lesions involving three vessels of coronary arteries were independent risk factors for MACE after PCI in patients with STEMI (all P<0.05). ROC analysis showed that the AUC for MPV (threshold as 0.86 fl) combined with Gensini score (threshold as 82.17) in predicting MACE in patients with STEMI after PCI was 0.92(95%CI [0.87, 0.98]), the sensitivity and specificity was 92.70% and 83.33%, respectively. Conclusion The occurrence of MACE in patients with STEMI after emergency PCI is related to MPV and Gensini score before intervention. MPV combined with Gensini score can be used to screen out high-risk patients.