Meta-analysis of efficacy evaluation of traditional Chinese medicine combined with Western medicine in the treatment of traumatic optic neuropathy / 国际眼科杂志(Guoji Yanke Zazhi)

ABSTRACT

@#AIM: To evaluate the efficacy and safety of traditional Chinese medicine combined with Western medicine(TCM-WM)in the treatment of traumatic optic neuropathy(TON).<p>METHODS:The computer searched PubMed, EMBASE, Cochrane Library, Chinese Biomedical Literature Database(CBM), Wan-Fang Database, China National Knowledge Infrastructure(CNKI)database and Weipu database. Search time was limited from their inception to May 2020. A comprehensive search strategy was designed to identify all randomized controlled trials(RCTs)comparing TCM-WM therapy versus WM therapy alone. The methodological quality of the included trials was assessed by the quality grade evaluation used in Cochrane handbook. Data extraction and Meta-analysis were performed by RevMan5.3 statistical software.<p>RESULTS: Twelve RCTs were included. The Meta-analysis showed that compared with the WM therapy alone in treating TON, TCM-WM therapy was better in improving the effective rate \〖<i>RR</i>=1.33, 95% <i>CI</i>(1.23-1.45), <i>P</i><0.001\〗, visual acuity \〖<i>MD</i>=0.18,95% <i>CI</i>(0.14-0.23), <i>P</i><0.001\〗, visual field mean defect \〖<i>MD</i>=-3.08, 95% <i>CI</i>(-5.20-0.96), <i>P</i>=0.004\〗, P₁₀₀ lantency \〖<i>MD</i>=-9.47, 95% <i>CI</i>(-16.37-2.57), <i>P</i>=0.007\〗 as well as P₁₀₀ amplitude \〖<i>MD</i>=1.44, 95% <i>CI </i>(0.22-2.66), <i>P</i>=0.02\〗. Two researches reported the occurrence and treatment of adverse reactions, and the remaining included researches did not report the adverse reactions.<p>CONCLUSION:The TCM-WM therapy in treating TON is more effective compared with the WM therapy alone.