Characteristics and significance of hr-HPV distribution of HSIL and cervical cancer in Hainan / 公共卫生与预防医学

ABSTRACT

Objective To explore the characteristics and significance of human papillomavirus (HPV) and high-risk HPV infection in cervical high-grade squamous intraepithelial lesions (HSIL) and cervical cancer (CC) in Hainan, and to provide a reference for the prevention of HPV infection and cervical cancer screening. Methods From May 2017 to December 2019, 379 gynecological inpatients in our hospital were selected (as case group), including 220 cases in the HSIL group and 159 cases in the CC group. A total of 182 healthy females undergoing physical examination in the same period of time were selected as a control group. Using PCR technology and DNA reverse dot hybridization technology, the patients were tested for HPV-DNA subtypes which were divided into 13 high-risk types and 10 low-risk types according to HPV genotypes. The relationship between HSIL and CC of patients and high-risk HPV infection was analyzed. Results (1) The HPV infection rate of HSIL and CC patients in the case group (85.75%) was significantly higher than that in the control group (26.92%) (P50-year-old group were significantly higher than those in other age groups. (4) In both the case group and the control group, single subtype infection was higher than multiple infection (P<0.001). Conclusion HSIL and CC patients in this area are mainly infected with single subtype and high-risk HPV. The infection exhibited certain differences in different ages.