Pathogen infection and pathogenesis of Kawasaki disease / 国际儿科学杂志

ABSTRACT

Kawasaki disease,also known as mucous skin lymph node syndrome,is a systemic vascular inflammatory disease mainly occurring in children under the age of 5 years,which has become the main cause of the acquired heart disease in children.The etiology and pathogenesis of Kawasaki disease have not been clearly defined since the initial report of Kawasaki disease in 1967.In recent years,the epidemiology of Kawasaki disease has highly suggested that the pathogenesis of Kawasaki disease is related to infection.It is reported that there are dozens of pathogens known to be associated with Kawasaki disease,including bacteria,viruses,mycoplasma pneumoniae,chlamydia,etc.This article reviews the pathogens related to Kawasaki disease reported in recent years,aiming to introduce the pathogens that cause the Kawasaki disease and its association with coronary artery lesions (CALs),the main complication of Kawasaki disease,so as to provide clinical guidance for the research of Kawasaki disease pathogenesis.