Clinicopathological features and research progress of C1q nephropathy / 国际儿科学杂志

ABSTRACT

C1q nephropathy is a special type of glomerulonephritis, which characterized by massive deposition of C1q on glomerular mesangial.The pathological manifestations of C1q nephropathy are minimal change disease, focal segmental glomerulosclerosis and proliferative glomerulonephritis.C1q nephropathy is prone to hormone dependence or resistance, and the prognosis is not good relatively.The pathogenesis of the disease is not clear.The clinical manifestations are quite different.Glucocorticoid is still the first choice for treatment.Immunosuppressive agents are often used in patients with hormone dependence or resistance.It has been found that the rituximab has good curative effect on C1q nephropathy in recent years.Although the understanding and research on C1q nephropathy is deepening, there is still much controversy about whether to classify C1q nephropathy into a class of independent diseases and the clinical significance of their classification.In this paper, the pathogenesis, pathological histology, clinical characteristics, treatment and prognosis of C1q nephropathy are reviewed in order to have a better understanding of C1q nephropathy.