Clinical progress of hepatoblastoma with tumor thrombus in children / 国际儿科学杂志

ABSTRACT

Hepatoblastoma(HB)is the most common primary malignant liver tumor in children, 90% occurs within 5 years old.Its event-free survival rate within 3 years after comprehensive treatment can reach 60%~70%.As one of the clinical manifestations of high-risk HB, tumor thrombus of hepatic and endovascular system can existed in central veins, such as portal vein, vena cava and even atrium.HB often induces massive hemorrhage of upper digestive tract, refractory ascites, liver failure and other complications.It seriously affects prognosis.In recent years, surgery, comprehensive chemotherapy, interventional therapy, radiotherapy, radiofrequency ablation, targeted therapy and high intensity radiofrequency focused knife therapy have made progress.Tumor thrombus is still a common characteristic of refractory HB.In this review, we expound the clinical progress of pediatric HB with cancer thrombus in recent years in order to improve its treatment and prognosis.