Progress in etiology of congenital diarrheal disorders in children / 国际儿科学杂志

ABSTRACT

Chronic diarrhea in children can affect the absorption of multiple nutrients resulting in growth retardation and stunting.Many causes can lead to chronic diarrhea, and finding out the etiology is the premise of treatment.A new study classified chronic diarrhea in children as acquired diarrhea and congenital diarrheal disorders(CDDs). According to its pathophysiological characteristics, CDDs can be divided into defects of digestion, absorption and transport of nutrients or electrolytes, defects of intestinal epithelial enzymes and metabolic disorders, defects of absorptive enterocyte differentiation or polarization, defects of the enteroendocrine cells and defects of the immune system affecting the intestine.This review summarizes the advances in etiology of CDDs in children.