Survivin and the vascular remodeling of neonatal hypoxic pulmonary hypertension / 国际儿科学杂志

ABSTRACT

Neonatal hypoxic pulmonary hypertension(HPH) is a common critical illness in the neonatal intensive care unit.Its main pathological features are pulmonary vasospasm and late pulmonary vascular remodeling.The remodeled pulmonary vessels consolidate the increased pressure, which usually followed with right ventricular hypertrophy and heart failure, making them difficult to reverse.Studies have shown that survivin, as a vital hub of a series of proliferative signaling pathways, contributes to vascular remodeling and disease progression by regulating the apoptosis and proliferation of pulmonary vascular cells.This article reviews the research progress of the mechanism of survivin in neonatal HPH pulmonary vascular remodeling and aims to provide a new direction for the method of reversing neonatal HPH pulmonary vascular remodeling.