Advances in the effect of microRNA on regulating microglia activation and polarization / 国际儿科学杂志

ABSTRACT

MicroRNA is a group of endogenous non-coding RNAs with about 22 nucleotides, that participate in cell proliferation, differentiation, metabolism and apoptosis.Microglia are the specialized resident innate immune cells of the central nervous system, which mediate inflammation and immune response, and play an important role in the occurrence, development and rehabilitation of several nervous system diseases.Activated microglia can be polarized into two types M1 and M2.M1 polarized microglia mainly promotes inflammation, whereas M2 cells are characterized by anti-inflammation and tissue remodeling.In recent years, studies have demonstrated that miRNAs can regulate the process of microglia polarization and affect the progress of various nervous system diseases.The biological function of miRNAs and the regulation of microglia activation and polarization are reviewed in this paper.