Progress on chromosome abnormalities of children with neuroblastoma / 国际儿科学杂志

ABSTRACT

Neuroblastoma(NB)is the most common extracranial solid tumor in children, characterized by occult onset, high malignancy, and prone to bone, bone marrow and distant organ metastasis.It shows high heterogeneity in biology, genetics, clinic and morphology.So far, the prognosis of high-risk and refractory relapsed NB is still extremely poor.It has been found that various chromosome abnormalities were related to the occurrence, proliferation and metastasis of NB, including abnormalities chromosome number, gene structure , segmental fragmentation and chromatin remodeling.These researches speculated that the genetic variation among individuals during treatment might be one of the main reasons for tumor progression or recurrence.This study will review the molecular genetics related to chromosome abnormalities of NB and provide evidence for finding potential NB targets.